Shaodong Guo  is a Associate Professor,Texas A&M University,USA

Shaodong Guo

Associate Professor

Organizing Committee Member


Texas A&M University



Dr. Shaodong Guo is Associate Professor in the Department of Nutrition at Texas A&M University College. He received his Ph.D in Physiology from Peking University, China. Then he completed his postdoctoral research training in Genetics, Biochemistry, and Medicine in the Chinese Academy of Sciences, the University of Illinois at Chicago, and Harvard University, respectively. Dr. Guo was an Instructor in Medicine at Children's Hospital Boston and Harvard Medical School for two years prior to joining the faculty at Texas A&M Health Science Center. Currently, Dr. Guo served as senior editor for the Journal of Endocrinology and Journal of Molecular Endocrinology, two major official journals of Endocrine Society of Europe, UK, and Australia, and he is the textbook chapter writer for Metabolic Syndrome edited by Rexford Ahima and published by Springer in 2016. Dr. Guo lab research focuses on hormonal signal transduction, insulin resistance, gene transcriptional control of nutrient homeostasis, and cardiac dysfunction in diabetes. Dr. Guo has been working on the gene transcriptional regulation of metabolic homeostasis by insulin receptor substrate proteins (IRS) and forkhead FoxO transcription factors and he has been funded by American Diabetes Association (ADA), American Heart Association, and the National Institute of Health of USA. He is a recipient of ADA junior faculty award, career development award, and Richard R. Lee Award. His work has been published in a number of journals including the JBC, Endocrinology, Hypertension, Diabetes, Circulation Research, AJP, MCB, and Nature Medicine, receiving more than 6,000 citations from the Google Scholar.



  1. Guo S, Li H. Lipoxygenase and its role in sweet potato tubers infected by Ceratocystis fimbriata. Acata Phytopathologica Sinica 24 (4): 325-329, 1995.
  2. Guo S, Wu G, Wu X. Nucleotide sequence of a cDNA encoding the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase from Aegilops squarrosa. Plant Physiology 108 (3): 1319-1320, 1995. PMID:7630959.
  3. Guo S, Wu G, Wu X. Rubisco activity and the small subunit gene cloning and functional analysis of Agelops squarrosa. Acta Botanica Sinica 39 (3): 222-230, 1997.
  4. Li S, Guo S, Sun F. Novel gene expressed during early embryogenesis of zebrafish identified by mRNA differential display. Chinese Science Bulletin 43(11): 936-940, 1998.
  5. Li S, Guo S, Sun F. Expression pattern of a beta 2 tubulin gene in zebrafish embryos identified by whole mount in situ hybridization. Chinese Science Bulletin 43(22): 1894-1998.
  6. Cichy S, Uddin S, Danilkovich A, Guo S, Unterman T. Protein kinase B/Akt mediates effects of insulin on hepatic gene expression through a conserved insulin response sequence. J. Biol. Chem. 273 (11): 6482-6487, 1998. PMID:9497382.
  7. Rena G, Guo S, Cichy S, Unterman T, Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 274 (24),17179-17183, 1999. PMID:10358075.
  8. Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on IGF binding protein-1 promoter activity through a conserved insulin response sequence. J. Biol. Chem. 274 (24),17184-17192, 1999. PMID:10358076.
  9. Ghosh A, Lacson R, Liu P, Cichy S, Danilkovich A, Guo S, Unterman TG. A Nucleoprotein Complex containing CCAAT/Enhancer-binding Protein Interacts with an Insulin Response Sequence in the Insulin-like Growth Factor-binding Protein-1 Gene and Contributes to Insulin-regulated Gene Expression. J. Biol. Chem. 276: 8507–8515, 2001. PMID:11116147.
  10. Guo S, Cichy S, He X, Ghosh AK, Jonson P, Unterman T. Insulin suppresses transactivation by CAAT/enhancer-binding protein b(CEBPb): Signaling to p300/CREB binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPb. J. Biol. Chem. 276 (11): 8516-8523, 2001. PMID:11116148.
  11. Schmoll D, Walker K, Alessi D, Burchell A, Guo S, Unterman T, Walther R. Regulation of glucose-6-phosphatase gene expression by protein kinase Ba and the forkhead transcription factor FKHR: Evidence for insulin response unit (IRU)-dependent and independent effects of insulin on promoter activity. J. Biol. Chem. 275 (46): 36324-36333, 2000. PMID:10960473.
  12. Rena G, Prescott AR, Guo S, Cohen P, Unterman T. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating nuclear targeting 14-3-3 binding, transactivation and nuclear targeting. Biochem J. 354: 605-612, 2001. PMID:11237865.
  13. Woods VL, Rena G, Morrice N, Barthel A, Becker W, Guo S, Unterman T, Cohen P. DYRK1A phosphorylates the transcription factor FKHR at Ser 329, a novel in vivo phosphorylation site. Biochem. J. 355: 579-607, 2001. PMID:11311120.
  14. Yeagley D, Guo S, Unterman T, Quinn P. Gene and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced IGFBP-1 and PEPCK transcription: roles of forkhead and insulin response sequences. J. Biol. Chem. 276(36): 33705-33710, 2001. PMID:11445561.
  15. Zhang X, Gan L, Pan H, Guo S, He X, Olson ST, Mesecar A, Adam S, Unterman TG. Phosphorylation of serine 256 suppresses transactivation by FKHR (FoxO1) by multiple mechanisms: Direct and indirect effect on nuclear/cytoplasmic shuttling and DNA binding. J. Biol. Chem. 277 (47): 45276-45284, 2002. PMID:12228231.
  16. Li P, Lee H, Guo S, Unterman TG, Jenster G , Bai W .AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. Mol. Cell. Biol. 23 (1): 104-118, 2003. PMID:12482965.
  17. Abid R, Guo S, Walsh K, Aird WC. Vascular endothelial growth factor activates PI3Kinase/AKT/Forkhead signaling in endothelial cells. Arteriosler. Thromb. Vasc. Biol. 24: 1-8, 2004. PMID:14656735.
  18. Abid MR, Yano K, Guo S, Patel VI, Shrikhande G, Spokes KC, Ferran C, Aird WC. Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia. J. Biol. Chem. 280: 29864-29873, 2005. PMID:15961397
  19. Guo S, Lopez-Ilasaca M, Dzau VJ. Identification of Calcium-modulating Cyclophilin Ligand (CAML) as Transducer of AngiotensinII -mediated Nuclear Factor of Activated T Cells (NFAT) Activation. J. Biol. Chem. 280: 12536 – 12541, 2005. PMID:15668245
  20. Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin M, Parsons R, White MF. Phosphatase and Tensin Homolog Regulation of Islet Growth and Glucose Homeostasis. J. Biol. Chem. 280: 39388 – 39393, 2005. PMID:16170201.
  21. Zhang W, Patil S, Chauhan B, Guo S, Powell D, Le J, Klotsas A, Matika R, Xiao X, Franks R, Heidenreich K, Sajan M, Farese R, Stolz D, Tso P, Koo SH, Montminy M, Unterman TG. FoxO1 Regulates Multiple Metabolic Pathways in the Liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 281: 10105 – 10117, 2006. PMID:16492665.
  22. Guo S, Dun S, White MF. The stability of Irs2 and FoxO1 creates a regulatory circuit that regulates insulin action. Molecular Endocrinology 20 (12): 3389-3399, 2006. PMID:16916938.
  23. Dong, X, Copps, K, Guo S, Li, Y, Kollipara, R, DePinho, RA, White MF. Inactivation of hepatic FoxO1 by Irs1 and Irs2 signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metabolism 8: 65-76, 2008. PMID:18590693.
  24. Guo S, Copps K, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese R, White MF. Irs1-branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Molecular and Cellular Biology 29(18):5070-5083, 2009. PMID:19596788.
  25. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers J, Depinho R, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nature Medicine 15(11):1307-1311, 2009. PMID:19838201.
  26. Guo S. Insulin, Insulin Resistance, and Control of Diabetes Mellitus. China Medical Tribune (1): 7, 2010 (Chinese).
  27. Messmer-Blust AF, Philbrick MJ, Guo S, Wu J, He P, Guo S, Li J. RTEF-1 Attenuates Blood Glucose Levels by Regulating Insulin-Like Growth Factor Binding Protein-1 in the Endothelium. Circulation Research 111:991-1001, 2012. For editorial see page 951-953. PMID:22843786.
  28. Zhang, K, Li L, Qi Y, Zhu X, Gan B, DePinho R, Averitt T, Guo S. Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice. For editorial preview see page 549-510. Endocrinology 153 (2): 631-646, 2012.. PMID:22147007.
  29. Li X, Long D, Ji J, Yang W, Zeng Z, Guo S, Ji Z, Qi G, Chen S. Sample preparation for the metabolomics investigation of poly-gamma-glutamate-producing Bacillus licheniformis by GC-MS. Journal of Microbiological Methods 94: 61-67, 2013. PMID: 23628234.
  30. Guo S. Molecular Basis of Insulin Resistance: The role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications. Drug Discovery Today: Disease Mechanisms. 10(2): e27-e33, 2013. PMID:24015152.
  31. Qi Y, Zhu Q, Xu Z, Thomas C, Kumar R, Feng H, Dostal D, White MF, Baker K, Guo S. Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and is Controlled by p38α MAPK During Insulin Resistance. For editorial highlights see page 3646. (Highlighted on Faculty of 1000). Diabetes 62:3887-3900, 2013. PMID:24015152.
  32. Ma J, Zhang L, Tipton AR, Wu J, Qi Y, Messmer-Blust A, Philbrick M, Liu ST, Liu H, Li J, Guo S. Structural and Functional Analysis of the Related Transcriptional Enhancer Factor-1 (RTEF-1) and Nuclear Factor Kappa B (NF-κB) Interaction. American Journal of Physiology-Heart and Circulatory Physiology 306: H233-H242, 2014. PMID: 24213609.
  33. Guo S. Insulin Signaling, Resistance, and the Metabolic Syndrome: Insights from mouse models to disease mechanisms. J. Endocrinology 220(2):T1-23, 2014. PMID: 24281010.
  34. Guo S. Decoding Insulin Resistance and Metabolic Syndrome for Promising Therapeutic Intervention. J. Endocrinology 220 (2): E1-3, 2014. PMID 24431466.
  35. Guo S. Mechanisms of Heart Failure in Type 2 Diabetes Mellitus. Austin Journal of Clinical Cardiology 1 (1):1-2, 2014.
  36. Zhang L, He S, Guo S, Xie W, Xin R, Yu H, Yang F, Qiu J, Zhang D, Zhou S, Zhang K. Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1. Journal of Diabetes and its Complications 28(3):259-64, 2014. PMID: 24693981.
  37. Yu H, He X, Xie W, Xiong J, Sheng H, Guo S, Huang C, Zhang D, Zhang K.Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation. Can J Microbiol. 60(4):227-35. 2014. PMID:24693981.
  38. Guo S. Tissue-specific insulin resistance and associated mechanisms for metabolic syndrome. Journal of Third Military University, 36 (15): 1535-1542, 2014.
  39. Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, Defronzo RA, Deng C, White MF, Liu F, Dong LQ. APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor. Cell Report. 7(4):1227-38, 2014. PMID: 24813896.
  40. Qi, Y, Zhang, K, Xu, Z, Yong, Q, Wu, Y, Kumar, R, Baker, K, Zhu, Q, Chen, S, Guo, S. Novel Mechanism of Blood Pressure Regulation by Foxo1-Mediated Transcriptional Control of Hepatic Angiotensinogen. Hypertension 64 (5): 1131-1140, 2014. PMID: 25069665
  41. Qi, Y, Zhu, Q, Qi, Y, Zhang, K, Thomas, C, Wu, Y, Kumar, R, Baker, K, Xu, Z, Chen, S, Guo, S. Activation of Foxo1 by Insulin Resistance Promotes Cardiac Dysfunction and β-Myosin Heavy Chain Gene Expression. Circulation: Heart Failure (8):198-208, 2015. PMID:25477432.
  42. Xie, W, Wang, L, Dai, Q, Qi, Y, Hu, F, Guo, S*, Zhang, K* (2015). Activation of AMPK Restricts Coxsackievirus B3 Replication by Inhibiting Lipid Accumulation. Journal of Molecular and Cellular Cardiology 85:155-167, 2015. *co-corresponding author
  43. Drosatos, K, Pollak, M, Pol, C, Ntziachristos, P, Willecke, F, Valenti, M, Trent, C, Hu, Y, Guo, S, Aifantis, I, Goldberg, I. Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function. Circulation Research (118):241-253. 2016. PMID: 26574507.
  44. Xiang J, Wang H, Ma C, Zhou M, Wu Y, Wang L, Guo S, Chen T, Shaw C. Ex Vivo Smooth Muscle Pharmacological Effects of a Novel Bradykinin-Related Peptide, and Its Analogue, from Chinese Large Odorous Frog, Odorrana livida Skin Secretions. Toxins (Basel). 2016 Sep 27;8(10). pii: E283. PMID:27690099
  45. Wang M, Luo L, Yao L, Wang C, Jiang K, Liu X, Xu M, Shen N, Guo S, Sun C, Yang Y. Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus. Scientific Report 2016 May 5;6:25399. PMID: 27145908.
  46. Wu Y, Long Q, Xu Y, Guo S, Chen T, Wang L, Zhou M, Zhang Y, Shaw C, Walker B. A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from OdorranaSchmackeri. Biosci Rep. 2017 Mar 29. pii: BSR20160593. doi: 10.1042/BSR20160593
  47. Pradhan G, Wu CS, Han Lee J, Kanikarla P, Guo S, Yechoor VK, Samson SL, Sun Y Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R. Scientific Report. 2017 Apr 20;7(1):979. doi: 10.1038/s41598-017-00888-0. PMID: 28428639
  48. Wu CS, Bongmba OYN, Yue J, Lee JH, Lin L, Saito K, Pradhan G, Li DP, Pan HL, Xu A, Guo S, Xu Y, Sun Y. Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis Int J Mol Sci. 2017 Apr 14;18(4). pii: E832. doi: 10.3390/ijms18040832. PMID:28420089.
  49. Ganugula R, Arora M, Jaisamut P, Wiwattanapatapee R, Jørgensen HG, Venkatpurwar VP, Zhou B, Rodrigues Hoffmann A, Basu R, Guo S, Ravi Kumar MNV Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic ß-cells for effective management of type 1 diabetes mellitus. Br J Pharmacology 174 (13):2074-2084, 2017. PMID: 28409821
  50. Guo CA, Guo S. Insulin receptor substrate signaling controls cardiac energy metabolism and heart failure. Journal of Endocrinology, (233):R131-R143, 2017.
  51. Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nature Communication 2017 Jul 25;8(1):131. doi: 10.1038/s41467-017-00163-w.PMID:28743992
  52. Long M, Cai L, Li W, Zhang L, Guo S, Zhang R, Zheng Y, Liu X, Wang M, Zhou X, Wang H, Li X, Li L, Zhu Z, Yang G, Zheng H. DPP-4 Inhibitors Improve Diabetic Wound Healing via Direct and Indirect Promotion of Epithelial-Mesenchymal Transition and Reduction of Scarring. Diabetes. 67 (3): 518-531, 2018.
  53. Cai Y, Li H, Liu M, Pei Y, Zheng J, Zhou J, Luo X, Huang W, Ma L, Yang Q, Guo S, Xiao X, Li Q, Zeng T, Meng F, Francis H, Glaser S, Chen L, Huo Y, Alpini G, Wu C. Disruption of Adenosine 2A Receptor Exacerbates NAFLD through Increasing Inflammatory Responses and SREBP1c Activity. Hepatology. 2018, 68 (1): 48-61. PMID:29315766.
  54. Zhang H, Shi JH, Jiang H, Wang K, Lu JY, Jiang X, Ma X, Chen YX, Ren AJ, Zheng J, Xie Z, Guo S, Xu X, Zhang W. ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration. Cell Death Disease 2018, 9(5):462. doi: 10.1038/s41419-018-0514-0.
  55. Chen J, Zhong L, Wu J, Sui Ke, Morpurgo B, Golovko A, Ouyang N, Sun Y, S Guo, Y Tian. A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals. Journal of Visualized Experiments (JoVE). 2018, e57327: 1-7.
  56. Wu Y, Pan Q, Yan H, Zhang K, Guo X, Xu Z, Yang W, Qi Y, Guo CA, Hornsby C, Zhang L, Zhou A, Li L, Chen Y, Zhang W, Sun Y, Zheng H, Wondisford F, He L, Guo S. Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis. Diabetes 2018, 67(11):2167-2182. doi: 10.2337/db18-0674. PMID:30201683.
  57. Fang C, Xu H, Guo S, Mertens-Talcott SU, Sun Y. Ghrelin Signaling in Immunometabolism and Inflamm-Aging. Adv Exp Med Biol. 2018, 1090:165-182. doi: 10.1007/978-981-13-1286-1_9. PMID: 30390290.
  58. Wu CS, Wei Q, Wang H, Kim DM, Balderas M, Wu G, Lawler J, Safe S, Guo S, Devaraj S, Chen Z, Sun Y. Protective effects of ghrelin on fasting-induced muscle atrophy in aging mice. J Gerontol. 2018, doi: 10.1093/gerona/gly256. [Epub ahead of print]. PMID: 30407483.
  59. Yan, H, Zhou, F, YangW, Li, X, Pan, Q, Shen, Z, Han, G, Newell-Fugate, A, Wu, C, Majeti,R, Xu, Y, Tian, Y, Allred, K, Allred, C, Sun, Y, Guo, S. Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1. Diabetes 2019, 68:291-304. doi: 10.2337/db18-0638.
  60. Xu, H, Li, X, Adams, H, Kubena, K, Guo, S. Etiology of Metabolic Syndrome and Dietary Intervention. International Journal of Molecular Sciences 2019, 20, 128:1-19. doi:10.3390.
  61. Li, X, Chen, Y, Shen, Z, Pan, Q, Yang, W, Yan, H, Liu, H, Ai, W, Liao, W, Guo, S. Epigallocatechin gallate inhibits hepatic glucose production in primary hepatocytes via downregulating PKA signaling pathway and transcriptional factor FoxO1 Journal of Agriculture and Food Science 2019, 67(13):3651-3661. doi: 10.1021/acs.jafc.9b00395. Epub 2019 Mar 21. PMID:30875211
  62. Zhang, K, Guo, S, Yan, H, Wu, Y, Pan, Q, Shen, Z, Li, X, Chen, Y, Li, L, Qi, Y, Xu, Z, Xie, W, Zhang, W, Threadgill D, He, L, Villarreal, D, Sun, Y, White, M, Zheng, H, Guo, S. Phosphorylation of forkhead protein FoxO1 at Ser 253 regulates glucose homeostasis in mice. Endocrinology 2019, 160 (5): 1333-1347. doi: 10.1210. PMID: 30951171
  63. Yang, W, Yan, H, Pan, Q, Shen, Z, Zhou, F, Wu, C, Sun, Y, Guo, S. Glucagon regulates hepatic mitochondrial function and biogenesis through Foxo1. Journal of Endocrinology 2019, 241: 265-278. doi: 10.1530/JOE-19-0081. PMID:31026811
  64. Zhou J, Li H, Cai Y, Ma L, Mathews D, Lu B, Zhu B, Chen Y, Qian X, Xiao X, Li Q, Guo, S, Huo Y, Zhao L, Tian Y, Li Q, Wu C. Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH. Journal of Endocrinology, 2019 Sep 1. pii: JOE-19-0198.R1. doi: 10.1530/JOE-19-0198. [Epub ahead of print] PMID: 31505462
  65. Liu H, Liu M, Jin Z, Yaqoob S, Zheng M, Cai D, Liu J, Guo, S. Ginsenoside Rg2 inhibits adipogenesis in 3T3-L1 preadipocytes and suppresses obesity in high-fat-diet-induced obese mice through the AMPK pathway. Food Funct. 2019 Jun 19;10(6):3603-3614. doi: 10.1039/c9fo00027e.PMID: 31161181
  66. Y Wang, H An, T Liu, C Qin, H Sesaki, S Guo, S Radovick, M Hussain, L HE. Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK, Cell reports 29 (6), 1511-1523. e5
  67. D Villarreal, G Pradhan, CS Wu, CD Allred, S Guo, Y Sun. A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice. JoVE (Journal of Visualized Experiments), e57048.
  68. Liao X, Song L, Zeng B, Liu B, Qiu Y, Qu H, Zheng Y, Long M, Zhou H, Wang Y, Du Y, Xu J, Shen R, Tong Q, Cai L, Li X, Guo S, Yang G, Zhu Z, Pu X, Wei H, Zheng H. Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis. EBioMedicine. 2019 Jun;44:665-674. doi: 10.1016/j.ebiom.2019.03.057. Epub 2019 Mar 26.
  69. Li X, Chan LWC, Li X, Liu C, Yang G, Gao J, Dai M, Wang Y, Xie Z, Liu J, Zhou F, Zheng T, Feng D, Guo S, Li H, Sun K, Yang S. Obesity-Induced Regulator of Calcineurin 1 Overexpression Leads to β-Cell Failure Through Mitophagy Pathway Inhibition. Antioxid Redox Signal. 2020 Mar 1;32(7):413-428. doi: 10.1089/ars.2019.7806.PMID: 31822118



1985:- High School of Enshi, Hubei Province, China

1989:- B.S. Huazhong Agricultural University (Agronomy), Wuhan, China

1992:- M.S. Huazhong Agricultural University (Physiology &Biochemistry). Mentor: Hesheng Li. Dissertation Title: Lipoxygenase and its role in fungal infection.

1995:- Ph.D. Peking University, Beijing, China (Physiology). Mentor: Xiangyu Wu. Dissertation Title: Structure and Function of Enzyme Rubisco



  • Mechanisms of Insulin Resistance and Diabetes Mellitus
  • Fatty Liver, Metabolic Syndrome and Disease
  • Diabetic Cardiomyopathy and Heart Failure
  • Nutrient and Hormonal Signaling and Biology
  • Nutritional and Therapeutic Intervention of Metabolic/Cardiac Diseases
  • Hypertension



1992-1995:- Winner of Guanghua Scholarship for outstanding Ph.D. student, Peking University, Beijing, China

1997-1999:- Young Investigator Award, Institute of Genetics and Developmental Biology of Chinese Academy of Sciences, Beijing, China

1997-1999:- Young Investigator Award, National Natural Science Foundation of China

1999:- American 81st Annual Meeting of Endocrine Society Competitive Travel Award

2007-2010:- American Diabetes Association Junior Faculty Award

2015-2020:- American Diabetes Association Career Development Award

2015:- American Diabetes Association Research Excellent Thomas R Lee Award

2019:- Distinguish Reviewer Award from the American Diabetes Association