BROCHURE
Ludis Morales  is a Staff Titular Professor,Javeriana University,Colombia

Ludis Morales

Staff Titular Professor

Organizing Committee Member

Colombia

Javeriana University

BIOGRAPHY

 

Ludis Morales, Ph.D is a Titular staff profesor of Biochemistry and an affiliate member of the Nutrition and Biochemisry Department at Universidad Javeriana in Bogotá, Colombia. She received an undergraduate degree in Biology and Chemistry and received her Ph.D. in Biological Sciences at the University of Javeriana. During her doctoral studies she had an excellent research training in the University of Florida, College of Medicine, Department of Pharmacology and Therapeutics, US.

 

Dr. Morales laboratory has a priority in evaluating molecules with therapeutic potential. The focus on her research group includes undestanding the mechanisms of signaling and regulation of receptor-ligand interactions associated with angiogenesis and proliferation. She has 40 publications among international and national journals.

 

Besides her wide experience as a senior researcher, Dr. Morales has an extensive experience (more than 20 years) teaching to graduate and undergraduate students, being also mentor of several master and Ph.D students. She has been in several administrative positions, the last one as the Head of the Nutrition and Biochemistry Department for 8 years at Javeriana University. She also owns special experience in evaluating, developing and management research projects.

PUBLICATIONS

 

  1. Angie C. Romero-Arias, Luis G. Sequeda-Castañeda, Andres F. Aristizábal-Pachón, and Ludis Morales*. Efect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells. Pharmaceuticals 2019, 12, 131.
  2. Ayala, Juan C., Morales, Ludis*. Mitochondrialdysfunction in ICU patients. Journalof International Medical Research. Submitted.
  3. Grismaldo Adriana, Morales Ludis*. Moléculas moduladoras de vías de señalización basales y desencadenadas por el Factor de Crecimiento Derivado de plaquetas (PDGF) en un modelo de fibrosarcoma humano. Revista de Nutrición Clínica y Metabolismo. 2018; 1(1):42-52.
  4. Schuler Ingrid, Constantino-Chuaire Sandra, Morales Ludis*. Social acceptance of genetically modified foods: an issue of scientific culture.  Submitted. Technology in Society,.
  5. Angie Romero, Milena Forero, Luis G. Sequeda-Castañeda, Adriana Grismaldo, José Iglesias, Crispín A. Celis-Zambrano, Ingrid Schuler, Ludis Morales*. Effect of ginger extract on membrane potential changes and AKT activation on a peroxide-induced oxidative stress cell model. Journalof King SaudUniversity – Science 30 (2018) 263–269
  6. González Margarita, Sequeda Luis G., Celis Crispin, Iglesias, José, Morales, Ludis*. Cytotoxic and antioxidant capacity of extracts from Vaccinium meridionale Swartz (Ericaceae) in transformed leukemia cell lines. Journal of Applied Pharmaceutical Science Vol. 7 (03), pp. 024-030, March, 2017.
  7. Velez J, Pan R, Lee JT, Enciso L, Suarez M, Duque JE, Jaramillo D, Lopez C, Morales L, Bornmann W, Konopleva M, Krystal G, AndreeffM,Samudio I. Biguanides sensitize leukemia cells to ABT-737- induced apoptosis by inhibiting mitocondrial electron transport. Oncotarget. 2016 Aug 9;7(32):51435-51449.
  8. Iglesias, J; Morales, L.; Barreto, GE. Metabolic and inflammatory adaptation of reactive astrocytes: Role of PPARs. Mol Neurobiol. 2016 Mar 17.
  9. Sequeda, Luis Gonzalo; Barrera, Andrés; Celis, Crispín; Iglesias, José; Morales, Ludis*. Evaluation of antioxidant and cytotoxic activity of extracts from fruits in fibroblastoma HT1080 cell lines: four fruits with commercial potential in Colombia. Emirates Journal of Food and Agriculture. 2016. 28(2): 143-151.
  10. Aliev G, Daza J, Herrera AS, Carmen Arias Esparza MD, Morales L, Echeverria V, Bachurin SO, Barreto GE. Nanoparticles as Alternative Strategies for Drug Delivery to the Alzheimer Brain: Electron Microscopy Ultrastructural Analysis. CNS Neurol DisordDrug Targets. 2015;14(9):1235-42.
  11. Torrente D, Cabezas R, Avila M, Sanchez Y, Morales L, Ashraf GM, Barreto GE, Gonzalez J, Aliev G. MechanismsofPDGFRalphapromiscuity and PDGFRbetaspecificity in association with PDGFB. Front Biosci (Elite Ed). 2015 Jun 1; 7:434-46.
  12. Juliana Velez, Leonardo José Enciso, Marta Suarez, Michael Fiegl, Adriana Grismaldo, Catalina López, Alfonso Barreto, Claudia Cardozo, Pilar Palacios, Ludis Morales, Jorge Eduardo Duque, Jorge Uriel Carmona, Marina Konopleva, Michael Andreeff and Ismael Samudio. Platelets Promote Mitochondrial Uncoupling and Resistance to Apoptosis in Leukemia Cells: A Novel Paradigm for the Bone Marrow Microenvironment. Cancer Microenvironment, 7:79–90, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25112275.
  13. Avila MF, Torrente D, Cabezas R, Morales L, García-Segura LM, Gonzalez J, Barreto GE. Structural insights from GRP78-NF-κB binding interactions: a computational approach to understand a possible neuroprotective pathway in brain injuries. Journal of Theoretical Biology, 345:43-51, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24361327.
  14. Sabogal-Arango A, Barreto GE, Ramírez-Sánchez D, González-Mendoza J, Barreto V, Morales L, González J. Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel. Bioinformatics and Biology Insights. 8:               73-81, 2014.
  15. Torrente D, Avila M, Cabezas R, Morales L, Gonzalez J, Samudio I, Barreto G. Paracrinefactors of humanmesenchymalstemcellsincreasewoundclosure and reducereactiveoxygenspeciesproduction in a traumaticbraininjury in vitromodel. Hum ExpToxicol. 2013 Oct 31;33(7):673-684. [Epubaheadofprint].
  16. Ricardo Cabezas, Marco Fidel Avila, Daniel Torrente, Ramon Santos El-Bachá, Ludis Morales, Janneth Gonzalez, George E Barreto. Astrocytes Role in Parkinson´s Disease: A double-edged sword. 05 / 2013; DOI:10.5772/54305 ISBN: 978-953-51-1088-0 In book: Neurodegenerative Diseases, Chapter: Astrocytes Role in Parkinson: A Double-Edged Sword, Publisher: Intech.
  17. Marco Fidel Avila, Ricardo Cabezas, Daniel Torrente, Janneth Gonzalez, Ludis Morales, Lisandro Alvarez, Francisco Capani and George E. Barreto. Novel interactions of GRP78: UPR and estrogen responses in the brain. Cell Biology International Volume 37, Issue 6, pages 521–532, June 2013.
  18. Janneth González, Angela Gálvez, Ludis Morales, George E. Barreto, Francisco Capani, Omar Sierra and Yolima Torres. Integrative Approach for Computationally Inferring Interactions between the Alpha and Beta Subunits of the Calcium-Activated Potassium Channel (BK): a Docking Study. Bioinformatics and Biology Insights 2013: 7 73–82.
  19. Sutachan JJ, Casas Z, Albarracin SL, Stab BR 2nd, Samudio I, Gonzalez J, Morales L, Barreto GE. Cellular and molecular mechanisms of antioxidants in Parkinson’s disease. Nutr Neurosci. 2012 May; 15(3):120-6.
  20. Barreto, Leidy Viviana; Barreto, George Emílio; Morales, Ludis; Acevedo, Orlando Emilio; González Santos, Janneth. Proteina LIC10494 de LeptospirainterrogansserovarCopenhageni: modelo structural y regiones funcionales asociadas. UniversitasScientiarum, vol. 17, núm. 1, enero-abril, 2012, pp. 16-27. http://www.redalyc.org/articulo.oa?id=49923387002.
  21. Barreto GE, Gonzalez J, Capani F, Morales L. Neuroprotective agents in brain injury: a partial failure. Int J Neurosci. 2012 May;122(5):223-6.
  22. Albarracin SL, Stab B, Casas Z, Sutachan JJ, Samudio I, Gonzalez J, Gonzalo L, Capani F, Morales L, Barreto GE. Effects of natural antioxidants in neurodegenerative diseases. Nutr Neurosci. 2012 Jan;15(1):1-9.
  23. George Barreto, Janneth González, Yolima Torres, L. Morales*.  Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury. Neuroscience Research 71 (2011) 107-113.
  24. Gjumrakch Aliev, Hector Palacios, Eldar Gasimov, Mark Obrenovich, Ludis Morales, Jersy Leszek, Valentin Bragin, Arturo Solis and Dmitry Gokhman. Oxidative stress induced mitochondrial failure and vascular hypoperfusion as a key initiator for the development of Alzheimer Disease. Pharmaceuticals 2010, 3, 158-187.
  25. Jairo Tovar, Maria Juliana Salamanca, Ludis Morales, Cecilia Espíndola. Regulación de la utilización del aspartato por los astrocitos durante la prelactancia. Universitas Scientiarum (2009) 14:2-3.
  26. Morales LA*, Obrenovich ME, Cobb CJ, Shenk JC, Méndez GM, Fischbach K, Smith MA, Qasimov EK, Perry  G. and Aliev G.Insights into Cerebrovascular Complications and Alzheimer Disease through the Selective Loss of GRK2 Regulation. J. Cell. Mol. Med. Vol 13, No 5, 2009 pp. 853-865.
  27. Ludis Morales*, Orlando Acevedo, María Martínez, Dmitry Gokhman. Functional discrimination of sea anemone neurotoxins using 3D-plotting. Cent. Eur. J. Biol. 4(1): 41–49, 2009.
  28. Shenk J.C., Liu J., Fischbach K., Xu K., Puchowicz M., Obrenovich M.E., Gasimov E., Ludis Morales Alvarez, Ames B.N., LaManna J.C. and Aliev G. The effect of Acetyl—L-Carnitine and R-alpha-Lipoic Acid Treatment in ApoE4 mouse as a model for human Alzheimer’s disease. Journal of the Neurological Sciences 2009, v. 283 (1-2), 199–206.
  29. Aliev G., Palacios H.H., Walrafen B, Lipsitt A.E., Obrenovich M.E. and Morales L.A. Brain Mitochondria as a Primary Target in the development of Treatment strategies for Alzheimer disease. International J.  Biochemistry & Cell Biology 41(2009) 1989-2004.
  30. Aliev G., Pacheco G., Palacios H.H., Perry G., Liu J., Obrenovich M.E., Corredor C., Qasimov E., Ames B.N., Morales L.A. Mitochondrialfailure as a primarypathogenetic factor in Alzheimer’sdiseasewhich can be diminished by selective mitochondrial antioxidants. Neurodegenerative Diseases, 2009, V. 6; No 3 (v.1-2), Suppl. 1: 1151.
  31. GjumrakchAliev, HectorPalacions, Amanda Lipsitt, KathrynFischbach, Bruce Lamb, Mark Obrenovich, Ludis Morales, EldarGasimov, ValentinBragin.  Nitric Oxide as an initiator of brain lesions during the development of Alzheimer disease. Neurotoxicity Research (2009) 16:293-305.
  32. GjumrakchAliev, Ludis Alvarez Morales,ValentinBragin, Jerzy Leszek and Joseph Charles LaManna (Eds). The Role ofoxidative stress, mitochondriafailure and cellularhypoperfusion in thepathobiologyofAlzheimer’sdisease 2009, ISBN978-81-308-0367-8. Publisher Research Signpost.
  33. Aliev, G., M.E. Obrenovich, L. Morales, C.J. Cobb, J. Daza, K. Fischbach, E. Gasimov (2009). “Lessons Learned for the Selective Loss of GRK2 Regulation and Consequent Cerebrovascular Complications and Alzheimer Disease”. The Role ofOxidativeStres, MitochondriaFailure, and CellularHypoperfusion in thePathobiology in Alzheimer’sdisease. Ed. G. Aliev et al. Publisher Research Signpost, Inc. Chapter 9 p 203-27.
  34. Ludis Morales A*., Gerardo Jesús Pacheco, Hector Palacios, Brianna Walrafen, Mark Erik Obrenovich, Eldar Qasimov, Joseph Charles LaManna and Gjumrakch Aliev.  Oxidative Stress-induced Mitochondrial Failure and Vasoactive Substances as Key initiators of Pathology Favor the Reclassification of Alzheimer Disease as a Vasocognopathy.   NOVA: PUBLICATION CIENTIFICA EN CIENCIAS BIOMEDICAS, VOL. 6, No10  JULIO-DICIEMBRE DE 2008: 105-236.
  35. Aliev G., Cobb C., Pacheco G., Shenk J.C, Moreira PI, Fischbach K.,Morales L.A., Gasimov E. and Perry G. The Role of Oxidative Stress and Vasoactive Substances in the Pathophysiology of Alzheimer’s Disease. In: BioMarkers for Early Diagnosis of Alzheimer's Disease, ISBN 978-1-60456-991-9 Editors: Daniela Galimberti and Elio Scarpini, 2008 Nova Science Publishers, Inc. Chapt.9,PP.241-265.
  36. Ludis Morales*, Jean Paul Vernot, Eliseo Amado. Detection by HPLC/UV of Prostaglandin E2 (PGE2) from biological fluids by esterification as p-bromophenacyl. Clon. V.3, No. 1: 24-36, 2006.
  37. L. Morales-Alvarez*, M. Ariza. Eventos de señalización asociados al Factor de Crecimiento Derivado de Plaquetas (PDGF). UniversitasScientiarum. Vol. 10, 5-20, 2005.
  38. Eliseo Amado González, Luis Hernando Blanco, Ludis Morales Alvarez. Modelación de datos de conductividad molar del electrolito simétrico Bu4Ni en mezclas de tolueno acetonitrilo a 25°C mediante la ecuación de Fuoss-Hsia. UniversitasScientiarum. Vol. 10, No.1, 25-36, 2005.
  39. R. Oyuela, L. Lareo, L. Muñoz, L. Morales, S. Echeverry, A. Uribe, O. Santos y A. Acuña. Efecto en el aprendizaje y la memoria espacial de un péptido sintético en ratas: Estudio preliminar. Psicología desde el Caribe. No. 13: 1-14, 2004.
  40. Eliseo Amado González, José Milciadez Díaz, Sandra Pérez, Ludis Morales*. Biosensores aplicados a la investigación enzimática. Clon. V.3: 107-111, 2004.

EDUCATION

 

2004:    Ph.D., Pontificia Universidad Javeriana–Bogotá/ Title of Ph.D. Thesis: Development of a model for the study of structure-function relationship of proteins: isolation, characterization and activity of a Caribbean sea anemone neurotoxin. Internship Fellow: Dpt. Pharmacology and Therapeutics, University of Florida, US

1993:    Graduate Student, Pontificia Universidad Javeriana–Bogotá. Master in Biochemistry. Title of MSc. Thesis: Picogram detection of Prostaglandin-E2 (PGE2) by HPLC / UV after conversión top-bromophenacylester.

1986:    Undergraduate in Chemistry and Biology, Universidad de la Salle – Bogotá

RESEARCH INTEREST

 

She is a profesional with training in Biochemistry and human cell physiology, as well as extensive experience in teaching in graduate and undergraduate courses. Also, has great expertise in evaluating and management research projects. She has a strong background in administrative positions, the last one as head of the Department of Biochemistry and Nutrition at the Pontificia Universidad Javeriana, for eight years.

 

Her research experience fundamentally lies in evaluating molecules with therapeutic potential, whether they come from a synthetic or natural source. Priorities of her research group include undestanding the mechanisms of signaling and regulation of receptor-ligand interactions associated with angiogenesis and proliferation. Finally, she has mentored undergraduate, masters, and doctoral studies.

HONORS AND AWARDS


2003: National Award in Basic Medical Sciences. Colombian Association of Biological Sciences.

2001. Award for Outstanding Professor. Department of Nutrition and Biochemistry. Pontificia Universidad Javeriana, Bogotá.

2000: 100% doctorate scholarship for merit to academic resume. The Ministry of Science, Technology and Innovation. COLCIENCIAS-Colombia

EDITORSHIP

  • Drug Target Insights, Reviewer 2016
  • Biochemistry insights, Reviewer 2015
  • Clinical Medicine Insights: Therapeutics, Reviewer 2015
  • Revista Universitas Scientiarum, Editorial Board Member, 2006
  • Revista Biomédica, Reviewer, 2005
  • Revista Biosalud, Reviewer, 2006